Tbx16 regulates hox gene activation in mesodermal progenitor cells

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Tbx16 regulates hox gene activation in mesodermal progenitor cells

The transcription factor T-box 16 (Tbx16, or Spadetail) is an essential regulator of paraxial mesoderm development in zebrafish (Danio rerio). Mesodermal progenitor cells (MPCs) fail to differentiate into trunk somites in tbx16 mutants and instead accumulate within the tailbud in an immature state. However, the mechanisms by which Tbx16 controls mesoderm patterning have remained enigmatic. We d...

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Hox transcription factors provide positional information during patterning of the anteroposterior axis. Hox transcription factors can co-operatively bind with PBC-class co-factors, enhancing specificity and affinity for their appropriate binding sites. The nuclear localisation of these co-factors is regulated by the Meis-class of homeodomain proteins. During development of the zebrafish hindbra...

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Mesodermal and spinal cord progenitors originate from common founder cells from which they segregate during development. Moreover, neural and mesodermal tissues closely interact during embryogenesis to ensure timely patterning and differentiation of both head and trunk structures. For instance, the fate and morphogenesis of neural progenitors is dependent on signals produced by mesodermal cells...

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FGF Signaling Controls Somite Boundary Position and Regulates Segmentation Clock Control of Spatiotemporal Hox Gene Activation

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ژورنال

عنوان ژورنال: Nature Chemical Biology

سال: 2016

ISSN: 1552-4450,1552-4469

DOI: 10.1038/nchembio.2124